Energy balance
Calorie restriction (CR) without malnutrition prevents or delays age-associated chronic diseases, including abdominal obesity, type 2 diabetes, hypertension, and cardiovascular diseases, in both non-human primates and humans.
To gain the anti-aging benefits of calorie restriction, reduce your daily calorie intake by 30-60% compared to your current maintenance level, but ensure you are eating nutrient-dense foods that provide 100% of your daily requirements for vitamins, minerals, and protein. This approach has been shown to protect against obesity, diabetes, and heart disease in both monkeys and humans.
In non-human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases.
Why this rating
Supported by randomized primate studies and human observational/metabolic studies, though human longevity data is lacking.
Source
Calorie restriction and prevention of age‐associated chronic disease
Daniela Omodei et al. · FEBS Letters · 2011
DOI 10.1016/j.febslet.2011.03.015
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- In humans, severe calorie restriction does not reduce serum IGF-1 levels unless protein intake is also reduced, whereas in rodents, CR reduces IGF-1 without protein restriction.Good
- Calorie restriction reduces oxidative damage to macromolecules (DNA, proteins, lipids) and down-regulates the insulin/IGF-1/mTOR signaling pathways, which are key mechanisms for extending healthspan and lifespan.Moderate
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