Mixed
Olive oil polyphenols (specifically oleuropein and hydroxytyrosol) act as caloric restriction mimetics by activating sirtuins (Sirt1), AMPK, and Nrf2 pathways, thereby inducing autophagy and reducing inflammation without actual caloric restriction.
Incorporate high-polyphenol extra virgin olive oil into your diet regularly. This provides compounds that mimic the cellular benefits of caloric restriction, such as improved metabolic health and reduced inflammation, without needing to drastically reduce food intake.
Plant polyphenols, including olive ones, induce CR-like effects in muscle, brain, fat tissue and kidney in several ways, particularly through the activation and increased levels of sirtuins (Sirt)... The data reviewed above indicate that most of the biochemical and physiological effects of plant polyphenols go well beyond their known antioxidant power and support mechanistically their apparent protection against a number of diseases.
Why this rating
Review of in vitro, animal, and some human studies; strong mechanistic data but limited large-scale human clinical trials for specific dosing.
Source
Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans
Stefania Rigacci et al. · International Journal of Molecular Sciences · 2016
DOI 10.3390/ijms17060843
More from this paper
- Olive polyphenols improve cardiovascular health by reducing lipid peroxidation, inhibiting atherosclerosis, lowering cholesterol and triglycerides, and improving post-prandial vascular function.Good
- Olive polyphenols (oleuropein and hydroxytyrosol) exhibit anti-cancer properties by inducing apoptosis, inhibiting angiogenesis, and preventing metastasis in various cancer cell types, including breast, prostate, and pancreatic cancer.Moderate
Related findings · Mixed
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