Research
Hormonal
Resveratrol extends lifespan in some model organisms (yeast, nematodes, fish) primarily through indirect mechanisms like SIRT1 activation and calorie restriction mimicry, rather than direct antioxidant action.
Resveratrol may offer longevity benefits in specific contexts (e.g., metabolic dysfunction), likely by mimicking calorie restriction via SIRT1 activation. However, it is not a direct antioxidant and its benefits in healthy humans are unproven. Prioritize calorie restriction and exercise, which robustly activate these same pathways.
GoodQualifiesMEDIUM confidence
RSV is capable of increasing the deacetylase activity of human sirtuin 1 (SIRT1)... RSV inhibits SIRT3, and it can mimic calorie restriction/dietary restriction (DR) effects... DR with adequate nutrition is the only nongenetic and the most consistent nonpharmacological intervention that extends lifespan.
Why this rating
Strong evidence in specific models (yeast, flies, fish) but mixed/absent in mammals.
Source
Effect of Antioxidants Supplementation on Aging and Longevity
Izabela Sadowska‐Bartosz et al. · BioMed Research International · 2014
DOI 10.1155/2014/404680
narrative_reviewCited 288×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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