Mixed
Genetic variants associated with obesity (such as FTO) explain less than 3% of BMI variation, failing to account for the 47-80% heritability estimates or the rapid global rise in obesity prevalence.
Do not blame your genetics for obesity. Current science shows that known genetic markers account for less than 3% of body weight variation. The rapid global increase in obesity is driven by environmental and lifestyle factors, not a sudden change in human DNA. This means your daily choices regarding diet and activity have a disproportionately large impact on your weight compared to your genetic predisposition.
the obesity-associated single nucleotide polymorphisms (SNPs) that have been identified to date explain less than 3% of the inherited susceptibility to develop an obese phenotype. This result is very far from the heritability estimates of body mass index (BMI) rounding 47–80%.
Why this rating
Based on large-scale GWAS meta-analyses and twin studies cited in a high-impact review.
Source
The contribution of genetics and environment to obesity
David Albuquerque et al. · British Medical Bulletin · 2017
DOI 10.1093/bmb/ldx022
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