Hormonal
Reduced GH/IGF-1 signaling protects against age-related diseases such as diabetes and cancer in both mice and humans with GH deficiency/resistance.
Humans with genetic GH deficiency are protected from diabetes and cancer, suggesting that lower GH/IGF-1 signaling might be protective. However, this comes with trade-offs like small stature. For the general population, this does not support GH supplementation for disease prevention, as excess GH may be harmful.
GH resistance or deficiency provides protection from major age-related diseases, including diabetes and cancer, in both species.
Why this rating
Strong evidence in mice; humans with GH deficiency are protected from diseases, though longevity data is lacking.
Source
Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity
Andrzej Bartke et al. · Physiological Reviews · 2013
DOI 10.1152/physrev.00006.2012
More from this paper
- Genetic deficiency or resistance to Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) signaling extends longevity and healthspan in laboratory mice.Good
- Reduced GH/IGF-1 signaling extends longevity in mice through mechanisms including enhanced stress resistance, reduced inflammation, and improved insulin signaling.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →