Research
Hormonal
Reduced GH/IGF-1 signaling extends longevity in mice through mechanisms including enhanced stress resistance, reduced inflammation, and improved insulin signaling.
The longevity benefits of low GH/IGF-1 signaling in mice are driven by better stress resistance, less inflammation, and better insulin sensitivity. This suggests that lifestyle factors improving these metrics (e.g., exercise, diet) may mimic some benefits of genetic deficiency.
GoodSupportsHIGH confidence
Mechanisms responsible for delayed aging of GH-related mutants include enhanced stress resistance and xenobiotic metabolism, reduced inflammation, improved insulin signaling, and various metabolic adjustments.
Why this rating
Well-supported in mouse models.
Source
Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity
Andrzej Bartke et al. · Physiological Reviews · 2013
DOI 10.1152/physrev.00006.2012
narrative_reviewCited 285×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Genetic deficiency or resistance to Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) signaling extends longevity and healthspan in laboratory mice.Good
- Reduced GH/IGF-1 signaling protects against age-related diseases such as diabetes and cancer in both mice and humans with GH deficiency/resistance.Good
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