Hormonal
Testosterone is the primary anabolic hormone responsible for skeletal muscle hypertrophy and strength gains, acting through genomic and non-genomic signaling pathways, whereas acute exercise-induced testosterone spikes are not the primary driver of these adaptations.
Focus on consistent resistance training and overall health rather than trying to manipulate acute hormonal spikes. Testosterone's role is foundational; if you have clinically low levels, medical intervention may be necessary, but for healthy individuals, the focus should be on the training stimulus and recovery, not chasing acute hormonal changes.
Testosterone (T) is an anabolic-androgenic steroid hormone that primarily interacts with androgen receptors (AR) in skeletal muscle... Testosterone performs a multitude of ergogenic, anabolic, and anti-catabolic functions in skeletal muscle and neuronal tissue leading to increased muscle strength, power, endurance, and hypertrophy in a dose-dependent manner (1).
Why this rating
The paper is a comprehensive review citing numerous human and animal studies, including AR knockout models and clinical trials, providing strong mechanistic and empirical support.
Source
Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise
William J. Kraemer et al. · Frontiers in Endocrinology · 2020
DOI 10.3389/fendo.2020.00033
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