Hormonal
Growth Hormone (GH) assay choice significantly impacts the interpretation of exercise-induced GH responses, with bioassays detecting much higher concentrations than immunoassays due to the presence of bioactive GH aggregates.
For most exercisers, this is a research note. However, it suggests that standard blood tests for GH may not fully capture the body's anabolic response to exercise. Do not rely on single GH blood draws to judge training effectiveness.
Plasma GH concentrations measured by this in vivo bioassay were estimated to be much greater (∼300x) than those measured by immunoassay. Further, in 1978 this group reported that a pituitary growth factor, which escaped detection by immunoassay, nevertheless had strong GH activity in the established rat tibia bioassay (95).
Why this rating
The paper cites specific historical studies (Ellis et al.) demonstrating the discrepancy between bioassays and immunoassays.
Source
Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise
William J. Kraemer et al. · Frontiers in Endocrinology · 2020
DOI 10.3389/fendo.2020.00033
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