Research
Mixed
Metformin is the most effective pharmacological adjunct for treating antipsychotic-induced weight gain, resulting in significant weight loss compared to placebo.
If you are gaining weight on antipsychotics, ask your doctor about metformin. It is the most proven medication to help counteract this specific type of weight gain and has a good safety profile. It works best when combined with lifestyle changes.
StrongSupportsHIGH confidence
Metformin was the most effective drug (-3.17 kg weight loss) compared with placebo... metformin may be considered for adjunctive therapy, given its favorable risk-benefit profile.
Why this rating
Supported by multiple meta-analyses of 40 trials.
Source
Weight gain and obesity in schizophrenia: epidemiology, pathobiology, and management
Peter Manu et al. · Acta Psychiatrica Scandinavica · 2015
narrative_reviewCited 283×
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