Mixed
Regular exercise prevents and treats cardiometabolic diseases, including obesity, type 2 diabetes, and cardiovascular disease, through pleiotropic effects on cardiorespiratory fitness and metabolic homeostasis.
Incorporate regular, structured physical activity into your routine to protect your heart and metabolic health. Focus on improving your cardiorespiratory fitness through a mix of aerobic and resistance exercises, as this combination is often more beneficial than either alone, especially for managing type 2 diabetes.
Regular exercise — a broad term reflecting structured, purposeful physical activity (8) — has proven effective in the prevention and treatment of cardiometabolic diseases.
Why this rating
The paper summarizes 'major findings from human exercise studies' and 'seminal randomized trials', though it notes gaps in specific dosing for certain populations.
Source
Exercise, exerkines, and cardiometabolic health: from individual players to a team sport
Jeremy Robbins et al. · Journal of Clinical Investigation · 2023
DOI 10.1172/jci168121
More from this paper
- Exercise stimulates the release of 'exerkines' (signaling molecules like IL-6, 12,13-diHOME, and musclin) that mediate systemic health benefits, including improved cardiac function and metabolic flexibility.Moderate
- High-volume and high-intensity exercise may increase the risk of atrial fibrillation (AF) in athletes, suggesting a J-shaped relationship between exercise volume and AF risk.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →