Research
Hormonal
miR-143 accelerates adipocyte differentiation and triglyceride accumulation, and its inhibition may slow down adipocyte differentiation and lipid droplet formation.
Research indicates that miR-143 accelerates fat cell differentiation and triglyceride accumulation. Inhibiting miR-143 might be a strategy to slow down fat cell development, though more human studies are needed.
ModerateSupportsMEDIUM confidence
Ectopic miR-143 expression during differentiation of 3T3-L1 pre-adipocytes resulted in twice the level of triglyceride accumulation early during differentiation.
Why this rating
Based on studies in 3T3-L1 pre-adipocytes and mouse models, but validation in humans is limited.
Source
microRNAs in the Regulation of Adipogenesis and Obesity
Robin A. McGregor et al. · Current Molecular Medicine · 2011
DOI 10.2174/156652411795677990
narrative_reviewCited 283×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- MicroRNAs (miRNAs) regulate adipogenesis and obesity by accelerating or inhibiting adipocyte differentiation and regulating fat cell numbers through post-transcriptional gene silencing.Moderate
- Specific microRNAs, such as miR-27 and miR-519d, target PPAR family members, which are well-established regulators of fat cell development.Moderate
- miR-27a and miR-27b suppress adipocyte differentiation by targeting PPARγ, and lower miR-27a expression in obese mice may be necessary for adipocyte hypertrophy.Moderate
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