Research
Hormonal
miR-27a and miR-27b suppress adipocyte differentiation by targeting PPARγ, and lower miR-27a expression in obese mice may be necessary for adipocyte hypertrophy.
miR-27a and miR-27b suppress fat cell differentiation by targeting PPARγ. Lower levels of miR-27a in obese mice suggest that suppressing these miRNAs might promote fat cell growth, while mimicking them could potentially reduce lipid storage.
ModerateRefutesMEDIUM confidence
overexpression of miR-27a in 3T3-L1 pre-adipocytes suppresses PPARγ expression and adipocyte differentiation.
Why this rating
Based on studies in 3T3-L1 pre-adipocytes and mouse models, but validation in humans is limited.
Source
microRNAs in the Regulation of Adipogenesis and Obesity
Robin A. McGregor et al. · Current Molecular Medicine · 2011
DOI 10.2174/156652411795677990
narrative_reviewCited 283×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- MicroRNAs (miRNAs) regulate adipogenesis and obesity by accelerating or inhibiting adipocyte differentiation and regulating fat cell numbers through post-transcriptional gene silencing.Moderate
- Specific microRNAs, such as miR-27 and miR-519d, target PPAR family members, which are well-established regulators of fat cell development.Moderate
- miR-143 accelerates adipocyte differentiation and triglyceride accumulation, and its inhibition may slow down adipocyte differentiation and lipid droplet formation.Moderate
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