Hormonal
High levels of proinflammatory cytokines TWEAK and TNF-α are associated with an increased risk of sarcopenia, while metabolic hormones IGF1, insulin, and adiponectin are associated with a decreased risk.
If you are over 60, getting your blood checked for inflammatory markers like TWEAK and TNF-α, and metabolic hormones like IGF1 and insulin, might provide a clearer picture of your muscle health risk than just looking at weight. High levels of these markers are linked to a much higher risk of sarcopenia. However, the good news is that lifestyle changes, specifically resistance training and whey protein supplementation, can significantly lower these inflammatory markers and improve muscle mass.
High levels of the inflammatory cytokines TWEAK and TNF-α are associated with an increased risk of sarcopenia, while the metabolic hormones insulin growth factor 1, insulin, and adiponectin are associated with a decreased risk of sarcopenia in our Chinese patient cohort.
Why this rating
Observational study with a relatively small sample size (n=56 sarcopenic, n=56 non-sarcopenic) but rigorous statistical adjustment for confounders.
Source
Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention
Chun‐wei Li et al. · Journal of Cachexia Sarcopenia and Muscle · 2019
DOI 10.1002/jcsm.12417
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