Hormonal
A 12-week intensive lifestyle intervention combining whey protein supplementation (30 g/day) and personalized resistance training significantly improves muscle mass and reduces proinflammatory cytokines (TWEAK, TNF-α, IL-18) while restoring metabolic hormone levels (adiponectin, insulin) in sarcopenic elderly patients.
For sarcopenic elderly individuals, a 12-week program combining 30g of whey protein daily (split around workouts) with 3 days of resistance training can significantly boost muscle mass and reduce harmful inflammation. The key is consistency and ensuring adequate protein intake (1.5g/kg/day) alongside strength exercises. This approach not only builds muscle but also improves the underlying hormonal and inflammatory drivers of muscle loss.
Intensive lifestyle interventions led to significant improvements in sarcopenic patients’ muscle mass and serum profiles of TWEAK, TNF-α, IL-18, insulin, and adiponectin (all P < 0.05).
Why this rating
Interventional study with a small sample size (n=32 completed intervention) but clear pre-post measurements and statistical significance.
Source
Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention
Chun‐wei Li et al. · Journal of Cachexia Sarcopenia and Muscle · 2019
DOI 10.1002/jcsm.12417
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