Research
Micronutrients & recovery
Betaine supplementation significantly lowers post-methionine load total homocysteine (tHcy) concentrations, with a stronger effect observed in individuals not receiving folic acid supplementation.
If you are not taking folic acid supplements, betaine supplementation (550mg) can help lower homocysteine levels, especially after a protein load. If you already take folic acid, betaine adds little extra benefit for homocysteine reduction.
GoodSupportsHIGH confidence
The effect of betaine on lowering post-methionine load tHcy is stronger than its effect on fasting tHcy [41]. The tHcy-lowering effect of betaine is higher in individuals not receiving folic acid.
Why this rating
Supported by multiple human studies cited (e.g., [41], [42]) showing dose-dependent effects, though the paper is a review.
Source
The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
Rima Obeid · Nutrients · 2013
narrative_reviewCited 278×
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