Mixed
GrimAge version 2 (GrimAge2), an epigenetic clock based on DNA methylation, is a superior predictor of all-cause mortality and age-related morbidity compared to the original GrimAge and other epigenetic clocks.
GrimAge2 is a blood test that measures your biological age based on DNA methylation patterns. It is a more accurate predictor of your risk for death and age-related diseases (like heart disease and diabetes) than your actual age or other aging clocks. While you cannot change your chronological age, your biological age can be influenced by lifestyle factors such as smoking, diet, and physical activity. Monitoring this metric can provide early warning signs of health decline, allowing for proactive lifestyle interventions.
After adjustment for age and sex, GrimAge2 outperforms GrimAge in predicting mortality across multiple racial/ethnic groups (meta P=3.6x10-167 versus P=2.6x10-144) and in terms of associations with age related conditions such as coronary heart disease, lung function measurement FEV1 (correlation= -0.31, P=1.1x10-136), computed tomography based measurements of fatty liver disease.
Why this rating
The study utilizes a massive validation dataset of 13,399 blood samples across nine independent cohorts with diverse racial/ethnic backgrounds, showing extremely high statistical significance (P values in the order of 10^-144 to 10^-167).
Source
DNA methylation GrimAge version 2
Ake T. Lu et al. · Aging · 2022
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