Energy balance
Reduction of adipocyte-derived SPARC protects against high-fat diet-induced obesity and metabolic dysfunction in female mice by enhancing energy expenditure and lipolysis.
This research identifies SPARC, a protein elevated in obesity, as a key regulator of fat storage. Reducing SPARC (naturally via caloric restriction or potentially via future therapies) may help manage weight by increasing energy expenditure and breaking down fat, particularly in women. While not a direct diet advice, it highlights that lowering this specific protein is linked to improved metabolic health.
Deletion of SPARC in adipocytes was sufficient to protect mice against HFD-induced adiposity, chronic inflammation, and metabolic dysfunction. ... reduction of SPARC in adult life protected against adiposity and may have conferred partial CR-like metabolic benefits on adipose tissue metabolism.
Why this rating
Strong mechanistic evidence in mouse models with clear phenotypic outcomes, though human translation is inferred from observational data.
Source
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
Seungjin Ryu et al. · Journal of Clinical Investigation · 2023
DOI 10.1172/jci169173
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