Energy balance
Endurance and resistance exercise training lowers plasma BCAA levels and enhances BCAA oxidation, serving as a natural strategy to mitigate BCAA-related insulin resistance.
Engage in regular endurance and resistance training. This naturally lowers circulating BCAA levels and improves their oxidation, helping to counteract insulin resistance. You don't need extreme protocols; consistent training is effective.
endurance exercise training in rodents... and combined endurance and resistance training in humans with overweight... decreased plasma BCAA levels... endurance training promotes the transamination of BCAA to BCKA... which are further metabolized into acyl-coenzymes which can enter the TCA cycle.
Why this rating
Supported by multiple studies in rodents and humans, including specific human trials showing decreased plasma BCAA levels.
Source
Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes
Froukje Vanweert et al. · Nutrition and Diabetes · 2022
DOI 10.1038/s41387-022-00213-3
More from this paper
- Elevated plasma branched-chain amino acid (BCAA) levels contribute to the development of insulin resistance through multiple mechanisms, including mTOR/S6K-mediated inhibition of insulin signaling, inhibition of pyruvate dehydrogenase (PDH), and accumulation of toxic metabolites causing mitochondrial dysfunction.Moderate
- Pharmacological activation of the BCKD complex using agents like BT2 or Sodium Phenylbutyrate (NaPB) accelerates BCAA catabolism, lowers plasma BCAA levels, and improves insulin sensitivity in animal models of obesity and diabetes.Moderate
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