Specific natural compounds, such as resveratrol, curcumin, and honey, improve glucose control and insulin sensitivity through mechanisms like activating sirtuins, inhibiting alpha-amylase, and reducing oxidative stress in pancreatic beta-cells.

Resveratrol... enhances insulin sensitivity by activation of deacetylases sirtuins 1–7, protects β-cells from oxidative stress, interacts with PPARγ receptor. Curcumin... supports pancreatic cell viability by inhibition of lipid peroxidation, NF-κB activation and reduction of inflammatory cytokine levels. Honey... hypoglycaemic properties are attributed to several mechanisms, the most important mechanism is based on fructose action... Honey has antioxidant properties and reduces oxidative stress in pancreatic β-cells.