Research
Hormonal
High baseline insulin secretion predicts greater long-term weight gain, particularly when consuming high-glycemic-index diets, supporting the carbohydrate-insulin model of obesity pathogenesis.
If you have high insulin levels, focus on reducing the glycemic load of your diet. High-glycemic foods may trigger excessive insulin secretion, promoting fat storage and weight gain, especially in those predisposed to insulin resistance.
GoodSupportsHIGH confidence
High insulin secretion in animal models correlates with greater weight gain when consuming a high-, but not low-, glycaemic-index diet [39]. ... people who had higher levels of insulin secretion at baseline gained the most weight [44,45].
Why this rating
Based on multiple prospective cohort studies and animal models cited in the review.
Source
The Metabolomic Signatures of Weight Change
Amrita Vijay et al. · Metabolites · 2019
DOI 10.3390/metabo9040067
narrative_reviewCited 24×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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