Research
Energy balance
Increased oxidative stress (ROS) and mitochondrial dysfunction are early markers of weight gain, potentially preceding other metabolic changes.
Be aware that long-term weight gain, especially from high-fat/sucrose diets, may increase oxidative stress and mitochondrial dysfunction, which can further promote weight gain. Addressing these underlying metabolic issues may be key to breaking the cycle.
ModerateSupportsMEDIUM confidence
The first stage in the metabolic changes that take place during long-term weight gain is an increase in ROS, which in turn results in the other changes that contribute to long-term weight gain and that are secondary to an increase in ROS [24].
Why this rating
Based on animal models and some human metabolomic studies.
Source
The Metabolomic Signatures of Weight Change
Amrita Vijay et al. · Metabolites · 2019
DOI 10.3390/metabo9040067
narrative_reviewCited 24×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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