Hormonal
Premenopausal women exhibit higher insulin-stimulated glucose uptake in skeletal muscle compared to men, a difference mediated by estradiol signaling and higher adiponectin levels.
If you are a healthy premenopausal woman, your body is biologically wired to handle insulin and glucose more efficiently in your muscles than a man's, largely due to estrogen. This is a protective factor against type 2 diabetes, but it does not negate the importance of maintaining muscle mass and fitness.
it seems to be a consistent finding that there is a higher glucose uptake in female skeletal muscle when stimulated by physiologic insulin concentrations.
Why this rating
Based on a review of multiple hyperinsulinemic-euglycemic clamp studies and molecular biology evidence.
Source
Gender Differences in Skeletal Muscle Substrate Metabolism – Molecular Mechanisms and Insulin Sensitivity
Anne‐Marie Lundsgaard et al. · Frontiers in Endocrinology · 2014
DOI 10.3389/fendo.2014.00195
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