Micronutrients & recovery
Augmentation of NAD+ levels via precursors (NR or NMN) restores mitophagy and extends lifespan in Werner syndrome models.
For individuals with genetic conditions affecting DNA repair (like Werner Syndrome) or those seeking to mitigate age-related metabolic decline, supplementing with NAD+ precursors like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) can restore cellular energy metabolism and extend healthspan. This is achieved by boosting NAD+ levels, which activates mitophagy (clearing of damaged mitochondria) via the DCT-1 and ULK-1 pathways, thereby delaying aging phenotypes.
NAD+ repletion restores NAD+ metabolic profiles and improves mitochondrial quality through DCT-1 and ULK-1-dependent mitophagy. At the organismal level, NAD+ repletion remarkably extends lifespan and delays accelerated aging, including stem cell dysfunction, in Caenorhabditis elegans and Drosophila melanogaster models of WS.
Why this rating
Strong evidence across human cell lines, plasma samples, and two distinct animal models (C. elegans, Drosophila), though no human clinical trial data is presented.
Source
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Evandro Fei Fang et al. · Nature Communications · 2019
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