Research
Hormonal
Promoting angiogenesis (healthy vascularization) in adipose tissue reduces inflammation and fibrosis, whereas suboptimal vascularization leads to hypoxia and insulin resistance.
Maintaining good blood flow to fat tissue through exercise and healthy lifestyle may help prevent the stiffening (fibrosis) of fat tissue, which is linked to insulin resistance.
GoodSupportsHIGH confidence
Most interestingly, promoting angiogenesis favors healthy adipose tissue expansion with enhanced adipogenesis and reduced adipose tissue inflammation and fibrosis.
Why this rating
Supported by multiple studies cited in the review.
Source
Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis
Geneviève Marcelin et al. · Journal of Clinical Investigation · 2019
DOI 10.1172/jci129192
narrative_reviewCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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