Research
Hormonal
Bariatric surgery-induced weight loss does not resolve adipose tissue fibrosis and may even increase ECM deposition, potentially contributing to metabolic deterioration during weight rebound.
Weight loss surgery reduces fat mass but may leave fat tissue stiff and inflamed. Long-term management should focus on maintaining metabolic health, not just weight loss, to mitigate fibrosis-related risks.
GoodQualifiesHIGH confidence
Surprisingly, analysis of human WAT revealed that weight loss induced by surgery is accompanied by increased deposition of ECM (133), suggesting that weight loss has a profound impact on tissue remodeling.
Why this rating
Based on human WAT analysis cited in the review.
Source
Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis
Geneviève Marcelin et al. · Journal of Clinical Investigation · 2019
DOI 10.1172/jci129192
narrative_reviewCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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