Micronutrients & recovery
Administration of ethanolamine increases intracellular phosphatidylethanolamine (PE) levels, which positively regulates autophagic flux and extends chronological lifespan in yeast, mammalian cells, and Drosophila.
To potentially support longevity and cellular cleanup (autophagy), consider increasing your intake of ethanolamine. This can be done through diet (foods rich in phosphatidylethanolamine precursors) or supplementation. Research in yeast, cells, and flies shows that 10 mM ethanolamine extends lifespan by about 5% in flies and boosts autophagy in mammalian cells. While human data is not yet available, ethanolamine is a naturally occurring compound with a favorable safety profile. It works by increasing levels of phosphatidylethanolamine (PE), which is essential for the autophagy process.
Conversely, the artificial increase of intracellular PE levels, by provision of its precursor ethanolamine or by overexpression of the PE-generating enzyme Psd1, significantly increased autophagic flux, both in yeast and in mammalian cell culture. Importantly administration of ethanolamine was sufficient to extend the lifespan of yeast (Saccharomyces cerevisiae), mammalian cells (U2OS, H4) and flies (Drosophila melanogaster).
Why this rating
Strong experimental evidence across multiple model organisms (yeast, mammalian cell lines, flies) with consistent results, though human clinical data is not provided.
Source
Phosphatidylethanolamine positively regulates autophagy and longevity
Patrick Rockenfeller et al. · Cell Death and Differentiation · 2015
DOI 10.1038/cdd.2014.219
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