Research
Hormonal
Inhibin A, secreted by macrophages or induced in preadipocytes, is a major profibrotic factor driving the synthesis of fibronectin and collagen I.
Inhibin A is identified as a specific protein that drives fat tissue scarring. This highlights a potential target for future therapies to reverse obesity-related fibrosis.
GoodSupportsHIGH confidence
Gene expression and neutralizing antibody experiments suggest that inhibin A, a TGF-beta family member, is a major fibrotic factor.
Why this rating
Supported by gene expression, real-time PCR, and neutralizing antibody experiments.
Source
Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes
Mayoura Kéophiphath et al. · Molecular Endocrinology · 2008
DOI 10.1210/me.2008-0183
mechanism_onlyCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Macrophage-secreted factors induce a profibrotic phenotype in human preadipocytes, characterized by increased proliferation, migration, and synthesis of extracellular matrix (ECM) proteins like fibronectin and collagen I.Good
- The fibronectin/integrin alpha5 partnership is essential for the proliferation of inflammatory preadipocytes.Good
- NF-kappaB and Cyclin D1 are critical molecular links connecting inflammation, ECM remodeling, and preadipocyte proliferation.Good
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