Research
Hormonal
NF-kappaB and Cyclin D1 are critical molecular links connecting inflammation, ECM remodeling, and preadipocyte proliferation.
Targeting NF-kappaB or Cyclin D1 pathways could potentially disrupt the cycle of inflammation and fibrosis in fat tissue.
GoodSupportsHIGH confidence
Small interfering RNA deletion of nuclear factor-kappaB and cyclin D1 showed that these factors link preadipocyte proliferation with inflammation and ECM remodeling.
Why this rating
Supported by siRNA knockdown experiments.
Source
Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes
Mayoura Kéophiphath et al. · Molecular Endocrinology · 2008
DOI 10.1210/me.2008-0183
mechanism_onlyCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Macrophage-secreted factors induce a profibrotic phenotype in human preadipocytes, characterized by increased proliferation, migration, and synthesis of extracellular matrix (ECM) proteins like fibronectin and collagen I.Good
- Inhibin A, secreted by macrophages or induced in preadipocytes, is a major profibrotic factor driving the synthesis of fibronectin and collagen I.Good
- The fibronectin/integrin alpha5 partnership is essential for the proliferation of inflammatory preadipocytes.Good
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