Research
Hormonal
Adiponectin levels are inversely correlated with adiposity and exert anticancer effects by decreasing insulin/IGF-1 signaling and reducing proinflammatory cytokine expression.
Higher levels of adiponectin, which are typically found in leaner individuals, are associated with lower cancer risk. This hormone helps regulate glucose metabolism and reduces inflammation.
GoodSupportsHIGH confidence
Unlike leptin, levels of adiponectin are negatively correlated with adiposity. Adiponectin functions to counter the metabolic profile associated with obesity by modulating glucose metabolism, increasing fatty acid oxidation and insulin sensitivity, and decreasing production of inflammatory cytokines associated with obesity.
Why this rating
Supported by multiple case-controlled studies and mechanistic data.
Source
The growing challenge of obesity and cancer: an inflammatory issue
Alison E. Harvey et al. · Annals of the New York Academy of Sciences · 2011
DOI 10.1111/j.1749-6632.2011.06096.x
narrative_reviewCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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