Research
Energy balance
Calorie restriction (20-40% reduction) inhibits carcinogenesis by modulating metabolic hormones (IGF-1, insulin, leptin, adiponectin) and decreasing inflammatory cytokine production.
Reducing calorie intake by 20-40% can lower cancer risk by improving hormone balance and reducing inflammation. If strict CR is too difficult, researchers are exploring drugs and natural products (like metformin or resveratrol) that might mimic these benefits.
GoodSupportsHIGH confidence
Calorie restriction (CR), a dietary regimen involving a reduction in total energy (typically 20–40%), is an effective way to increase life span of mammals and inhibit carcinogenesis.
Why this rating
Supported by extensive research in mammals and mechanistic studies in humans.
Source
The growing challenge of obesity and cancer: an inflammatory issue
Alison E. Harvey et al. · Annals of the New York Academy of Sciences · 2011
DOI 10.1111/j.1749-6632.2011.06096.x
narrative_reviewCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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