Hormonal
High luminal glucose concentrations trigger the translocation of the facilitative transporter GLUT2 to the brush border membrane (BBM) of enterocytes, thereby increasing the capacity for D-glucose absorption.
Your small intestine is designed to absorb glucose more efficiently when you consume a high-glucose meal. It does this by moving specific transporters (GLUT2) to the surface of the cells facing the gut lumen. This is a normal, healthy physiological response to maximize nutrient uptake from carbohydrate-rich foods.
whereas GLUT2 is localized in the basolateral membrane (BLM) or the BBM plus BLM at low and high luminal D-glucose concentrations, respectively... high-capacity D-glucose absorption at high luminal glucose is mediated by SGLT1 plus GLUT2 in the BBM and GLUT2 in the BLM.
Why this rating
The paper is a comprehensive review citing multiple studies across species (human, rodent) confirming this translocation.
Source
Glucose transporters in the small intestine in health and disease
Hermann Koepsell · Pflügers Archiv - European Journal of Physiology · 2020
DOI 10.1007/s00424-020-02439-5
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