Research
Hormonal
SGLT1 abundance in the brush border membrane increases in response to high luminal glucose, mediating high-capacity glucose absorption.
When you eat foods high in glucose, your body increases the number of SGLT1 transporters on the surface of your intestinal cells. This allows your body to absorb more glucose efficiently from your meal.
GoodSupportsHIGH confidence
At high luminal D-glucose, the abundance SGLT1 in the BBM is increased.
Why this rating
Supported by multiple studies cited in the review regarding SGLT1 regulation.
Source
Glucose transporters in the small intestine in health and disease
Hermann Koepsell · Pflügers Archiv - European Journal of Physiology · 2020
DOI 10.1007/s00424-020-02439-5
narrative_reviewCited 269×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High luminal glucose concentrations trigger the translocation of the facilitative transporter GLUT2 to the brush border membrane (BBM) of enterocytes, thereby increasing the capacity for D-glucose absorption.Good
- GLUT5 is the primary facilitative transporter responsible for D-fructose absorption in the small intestine.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →