Hormonal
Conjugated linoleic acid (CLA) supplementation, particularly the trans-10, cis-12 isomer, reduces body fat and adiposity in animal models through mechanisms involving PPAR modulation and SCD-1 inhibition, but in humans, it often fails to significantly affect body composition or insulin sensitivity and may induce adverse metabolic effects like hyperproinsulinemia.
CLA supplements are not a reliable solution for fat loss or metabolic health in humans. While they reduce fat in animals, human studies show minimal to no benefit on body composition and a potential risk of increased insulin resistance, particularly with the trans-10, cis-12 isomer. Focus on diet and exercise instead.
Studies in obese humans, however, show that CLA do not affect glucose metabolism or insulin sensitivity... In humans, although it is indicated that 10-CLA is the antiadipogenic isomer, the effects of CLA on fat deposition are less significant and more equivocal as compared to results observed in animals... In obese men, 10-CLA induces hyperproinsulinemia that is related to impaired insulin sensitivity
Why this rating
The paper is a review summarizing heterogeneous studies; human clinical trials show conflicting and often null results compared to strong animal data.
Source
Conjugated linoleic acids as functional food: an insight into their health benefits
Sailas Benjamin et al. · Nutrition & Metabolism · 2009
DOI 10.1186/1743-7075-6-36
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