Research
Hormonal
CLA supplementation modulates immune function by altering cytokine levels (increasing anti-inflammatory IL-10, decreasing pro-inflammatory TNF-alpha) and antibody responses, though short-term supplementation in healthy volunteers may not significantly alter overall immune status indices.
CLA may slightly alter specific immune markers like cytokines and antibodies, but it does not appear to provide a significant boost to overall immune function in healthy people. It is not a substitute for a healthy lifestyle in preventing illness.
ModerateSupportsMEDIUM confidence
Song et al. investigated the effect of dietary CLA supplementation... levels of plasma IgA and IgM were increased with decreased plasma IgE levels. CLA supplementation also decreased the levels of the proinflammatory cytokines, TNF-α and IL-1β, but increased the levels of the anti-inflammatory cytokine, IL-10.
Why this rating
Mixed results in human trials; some show immune changes, others show no effect on immune status indices.
Source
Conjugated linoleic acids as functional food: an insight into their health benefits
Sailas Benjamin et al. · Nutrition & Metabolism · 2009
DOI 10.1186/1743-7075-6-36
narrative_reviewCited 268×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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