Hormonal
Short-term reduction in daily physical activity (step reduction) induces peripheral insulin resistance and ectopic fat accumulation (liver and visceral adipose tissue) in young, healthy adults within 14 days.
Even if you are young and healthy, dropping your activity level significantly (e.g., from 10,000 to 1,500 steps/day) for just two weeks can cause your body to store fat in the liver and become less sensitive to insulin. This happens even if your total body weight doesn't change. To prevent this, try to maintain your usual activity level or incorporate light movement during periods of reduced activity.
Taken together, the evidence suggests that step reduction causes peripheral insulin resistance in skeletal muscle and adipose tissue, but while fat is accumulated centrally and in the liver, hepatic insulin resistance remains unchanged (in the short term).
Why this rating
Based on multiple controlled step-reduction studies in young healthy adults.
Source
Reduced physical activity in young and older adults: metabolic and musculoskeletal implications
Kelly A. Bowden Davies et al. · Therapeutic Advances in Endocrinology and Metabolism · 2019
DOI 10.1177/2042018819888824
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