Hormonal
Roux-en-Y gastric bypass (RYGB) surgery increases circulating bile acids and TGR5 signaling, but this increase does not significantly predict changes in glucose homeostasis (insulin sensitivity/secretion) or resting energy expenditure.
If you undergo Roux-en-Y gastric bypass, your body will produce significantly more bile acids. However, this specific increase does not appear to be the main reason your blood sugar control or energy expenditure improves. The metabolic benefits of this surgery likely come from other mechanisms, not just the bile acid surge.
Compared with LAGB, RYGB increases circulating BAs and TGR5 signaling, but this increase in BAs is not a significant predictor of changes in glucose homeostasis or energy metabolism.
Why this rating
Randomized controlled trial design with matched weight loss, rigorous metabolic clamps, and specific biochemical assays.
Source
Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids
Rohit Kohli et al. · The Journal of Clinical Endocrinology & Metabolism · 2013
DOI 10.1210/jc.2012-3736
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