Research
Hormonal
Roux-en-Y gastric bypass (RYGB) increases postprandial GLP-1 and decreases TSH, whereas Laparoscopic Adjustable Gastric Banding (LAGB) does not, despite both causing similar weight loss.
RYGB surgery changes your gut hormone (GLP-1) and thyroid hormone (TSH) levels more than LAGB does, even if you lose the same amount of weight. This suggests the surgery itself, not just the weight loss, affects how your body regulates energy and appetite.
GoodSupportsHIGH confidence
Surgery-induced changes in BAs were associated with increased peak postprandial plasma glucagon-like peptide-1 (r2 = 0.509, P < .001) and decreased serum TSH (r2 = 0.562, P < .001)... Plasma TSH decreased after weight loss induced by RYGB but not LAGB.
Why this rating
Strong study design with matched weight loss groups.
Source
Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids
Rohit Kohli et al. · The Journal of Clinical Endocrinology & Metabolism · 2013
DOI 10.1210/jc.2012-3736
cohort · n=18Cited 267×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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