Hormonal
Adiponectin, secreted by healthy PVAT, acts as a vasodilator by activating AdipoR1 receptors, stimulating AMPK and eNOS to produce nitric oxide, thereby lowering blood pressure and improving insulin sensitivity.
Maintaining healthy adipose tissue function is crucial. While direct adiponectin supplementation is not discussed as a standard therapy, lifestyle interventions that improve adipose tissue health (like exercise and weight loss) naturally boost adiponectin levels, aiding blood pressure control and insulin sensitivity.
Activation of AdipoR1 stimulates the production of AMPK... increased phosphorylation of endothelial nitric oxide synthase (eNOS)... leading to increased production of nitric oxide (NO)... leading to hyperpolarization and relaxation.
Why this rating
Supported by detailed mechanistic studies, knockout mice, and receptor-specific experiments.
Source
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Sophie N. Saxton et al. · Physiological Reviews · 2019
DOI 10.1152/physrev.00034.2018
More from this paper
- Perivascular adipose tissue (PVAT) dysfunction, characterized by reduced adiponectin secretion and increased pro-inflammatory cytokines, directly contributes to hypertension and insulin resistance by losing its anti-contractile effect on blood vessels.Good
- Visceral adipose tissue (VAT) is strongly associated with insulin resistance, dyslipidemia, and hypertension, independent of subcutaneous fat and BMI, due to its pro-inflammatory secretory profile.Good
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