Mixed
Adipose-derived mesenchymal stem cell (ADMSC) therapy reduces body weight and improves metabolic complications (diabetes, NAFLD) in animal models, though clinical efficacy remains controversial due to low cell survival rates.
ADMSC therapy shows promise in reducing weight and improving metabolic health in animal studies, but it is not yet a standard or proven treatment for humans. Clinical efficacy is controversial, and cell survival after transplantation is low. Patients should not expect this to be a current standard of care.
Numerous in vivo experiments have shown the efficiency of ADMSCs in weight loss and the reduction in body fat mass... However, the actual clinical efficacy of ADMSCs still remains controversial. Transplanted ADMSCs present a meager rate of survival and proliferation, possibly because of the damaged microenvironment of the affected tissues.
Why this rating
Based on numerous animal studies (Table 1) but explicitly stated as controversial in clinical settings.
Source
Gene Therapy Based on Mesenchymal Stem Cells Derived from Adipose Tissue for the Treatment of Obesity and Its Metabolic Complications
Marta Lopez‐Yus et al. · International Journal of Molecular Sciences · 2023
DOI 10.3390/ijms24087468
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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