Micronutrients & recovery
Oral supplementation with Nicotinamide Riboside (NR) at a dose of 1000 mg twice daily significantly increases whole-blood NAD+ levels in healthy adults.
Take 1000 mg of Nicotinamide Riboside (NR) twice daily. This dose has been shown to double whole-blood NAD+ levels in healthy adults without causing the side effects (like flushing) associated with other Vitamin B3 supplements. The study used an 8-day escalation protocol, but maintenance at 1000 mg BID is the effective dose for increasing NAD+.
Significant increases comparing baseline to mean concentrations at steady state (Cave,ss) were observed for both NR (p = 0.03) and NAD+ (p = 0.001); the latter increased by 100%.
Why this rating
Small sample size (n=8), open-label, non-randomized design, but uses rigorous pharmacokinetic methods.
Source
An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers
Sophia Airhart et al. · PLoS ONE · 2017
DOI 10.1371/journal.pone.0186459
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