Research

Mixed

Strenuous occupational activities, specifically fire suppression, training, and alarm response, significantly increase the relative risk of on-duty coronary heart disease (CHD) death in firefighters compared to non-emergency duties.

For high-stress occupations involving sudden bursts of extreme exertion (like firefighting, military combat, or heavy labor), the risk of cardiac events is not just about long-term health but about the acute trigger of strenuous activity. If you have underlying cardiovascular risk factors (age, smoking, hypertension), high-intensity bursts can precipitate failure. Regular medical screening and fitness maintenance are critical to handle these acute demands safely.

GoodSupportsHIGH confidence
Compared to non-emergency duties, fire suppression (OR = 64.1, 95% CI 7.4–556); training (OR = 7.6, 95% CI 1.8–31.3) and alarm response (OR = 5.6, 95% CI 1.1–28.8) carried significantly higher relative risks of CHD death.
Stefanos N. Kales et al. · Environmental Health · 2003

Why this rating

Case-control study with strong statistical significance and large effect sizes, though observational.

Source

Firefighters and on-duty deaths from coronary heart disease: a case control study

Stefanos N. Kales et al. · Environmental Health · 2003

DOI 10.1186/1476-069x-2-14

case_control · n=413Cited 265×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →