Hormonal
Dietary restriction and exercise delay aging by enhancing Sirtuin activity, which deacetylates histones and substrates to protect against age-related diseases and extend healthspan.
Adopting dietary restriction (without malnutrition) and regular exercise can boost Sirtuin activity. This metabolic shift helps maintain healthy gene expression patterns, potentially delaying the onset of age-related diseases like cancer and neurodegeneration. Focus on consistent lifestyle habits rather than quick fixes.
Sirtuins deacetylate many substrates, including histones, and their activity is enhanced when the ratio between nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide dehydrogenase is high, thereby linking chromatin regulation to reduced food intake (dietary restriction) and exercise (18), two environmental interventions that delay aging.
Why this rating
The paper is a perspective/review summarizing model organism studies (yeast, worms, flies) and human observational data, lacking direct large-scale human clinical trial evidence for reversal.
Source
Epigenetics of Aging and Aging-related Disease
Anne Brunet et al. · The Journals of Gerontology Series A · 2014
DOI 10.1093/gerona/glu042
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