Research
Hormonal
Cellular reprogramming to induced pluripotent stem cells (iPSCs) can model progeroid syndromes and reveal epigenetic defects associated with premature aging, offering a platform for screening epigenetic therapeutics.
iPSC technology allows scientists to study aging at a cellular level by creating stem cells from patients with premature aging syndromes. This helps identify potential drug targets but is not a treatment available to patients today.
ModerateSupportsMEDIUM confidence
Importantly, these iPC models can in turn be used to screen for epigenetic therapeutics to improve the epigenomic and cellular defects associated with premature aging.
Why this rating
Based on case studies of progeroid syndromes (Hutchinson-Gilford, Werner) using iPSC technology.
Source
Epigenetics of Aging and Aging-related Disease
Anne Brunet et al. · The Journals of Gerontology Series A · 2014
DOI 10.1093/gerona/glu042
narrative_reviewCited 264×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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