Research
Micronutrients & recovery
High intake of branched-chain amino acids (BCAAs) combined with a high-fat (western) diet may exacerbate metabolic disease risk by interfering with fatty acid oxidation and causing mitochondrial stress.
If you are eating a high-fat diet, be cautious with high BCAA intake or high-protein supplements, as this combination may worsen metabolic health. Prioritize reducing dietary fat before adding high levels of BCAAs.
ModerateQualifiesMEDIUM confidence
Metabolomics studies revealed that high intake of branched-chain amino acids (BCAAs, Valine, Leucine, Isoleucine) and aromatic amino acids (Phenylalanine, Tyrosine) may be associated with the development of metabolic diseases [80]. Importantly, this only occurs in combination with a high-fat diet.
Why this rating
Based on metabolomics studies and animal models cited in a review.
Source
A high-protein diet for reducing body fat: mechanisms and possible caveats
Dominik Pesta et al. · Nutrition & Metabolism · 2014
narrative_reviewCited 263×
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