Mixed

Higher baseline circulating levels of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are independently associated with a significantly increased risk of subsequent cardiovascular events (CVEs) and all-cause mortality.

High blood levels of TMAO are a strong warning sign for future heart problems and death, especially in people with existing heart or kidney disease. While you cannot directly 'dose' TMAO, you can influence it through diet (red meat/eggs increase it, seafood may not) and kidney health. If you have cardiovascular risk factors, discussing TMAO testing with your doctor might provide additional prognostic information, though it is not yet a standard screening tool for everyone.