Mixed
Myosteatosis is associated with insulin resistance, type-2 diabetes, hypertension, and dyslipidemia independent of total body adiposity (BMI or DXA whole body fat).
Metabolic health is not guaranteed by a normal BMI. Fat infiltration into muscles (myosteatosis) is a specific risk factor for diabetes and heart disease, independent of overall body fat. For those with normal weight but metabolic issues, assessing muscle quality (via imaging or functional proxies) may be necessary.
Independent of total body adiposity, measured either by body mass index (BMI) or dual energy X-ray absorptiometry (DXA) whole body fat, myosteatosis has been associated with insulin resistance and an increased risk of developing type-2 diabetes... hypertension... and dyslipidemia.
Why this rating
Synthesized from multiple observational studies cited in the symposium report.
Source
The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report
Rosaly Correa‐de‐Araujo et al. · Frontiers in Physiology · 2017
DOI 10.3389/fphys.2017.00087
More from this paper
- Increased intramuscular adipose tissue (myosteatosis) and intramyocellular lipids independently impair skeletal muscle function, force generation, and metabolic health in aging adults, often preceding loss of muscle mass.Good
- Current standardized assessment of muscle quality is lacking, with no single ideal endpoint measure, necessitating consensus on definitions and standardized imaging or functional tests.Moderate
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