Micronutrients & recovery
High dietary polyphenol intake, measured by urinary total polyphenol excretion (TPE), significantly decreases circulating inflammatory biomarkers (VCAM-1, ICAM-1, IL-6, TNF-α, MCP-1) associated with atherosclerosis in high-risk elderly individuals.
To reduce inflammation linked to heart disease, incorporate extra-virgin olive oil (about 1 liter per week for the household) or a daily handful of mixed nuts (walnuts, almonds, hazelnuts) into your diet. This specific increase in polyphenol intake, measured by how much your body excretes, is directly linked to lower levels of inflammatory markers like VCAM-1 and IL-6. This is most effective for older adults with existing cardiovascular risks.
Participants in the highest tertile of changes in urinary TPE (T3) showed significantly lower plasma levels of inflammatory biomarkers [vascular cell adhesion molecule 1 (VCAM-1) (–9.47 ng ml–1), intercellular adhesion molecule 1 (ICAM-1) (–14.71 ng ml–1), interleukin 6 (IL-6) (–1.21 pg ml–1), tumour necrosis factor alpha (TNF-α) (–7.05 pg ml–1) and monocyte chemotactic protein 1 (MCP-1) (–3.36 pg ml–1)] than those in the lowest tertile (T1, P < 0.02; all).
Why this rating
Randomized controlled substudy of a large, well-known trial (PREDIMED) with objective biomarkers (urinary TPE) and adjusted statistical models.
Source
Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial
Alexander Medina‐Remón et al. · British Journal of Clinical Pharmacology · 2016
DOI 10.1111/bcp.12986
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