Research
Hormonal
Self-renewal of satellite cells is regulated by asymmetric and symmetric division mechanisms, involving specific molecular pathways like p38 MAPK, Notch, and Wnt signaling, which determine whether a cell differentiates or self-renews.
Muscle repair relies on a delicate balance between using stem cells for repair and keeping some in reserve. This balance is controlled by complex molecular signals. Disrupting these signals (e.g., through aging or disease) can deplete the stem cell pool.
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The mechanisms regulating satellite cell self-renewal are exhibited in two different manners of cell division; one is by asymmetric division... The other is through symmetric division
Why this rating
Review of multiple primary studies detailing molecular mechanisms in mouse models.
Source
Muscle satellite cell heterogeneity and self-renewal
Norio Motohashi et al. · Frontiers in Cell and Developmental Biology · 2014
DOI 10.3389/fcell.2014.00001
narrative_reviewCited 259×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Muscle satellite cells are a heterogeneous population comprising distinct subpopulations with different self-renewal and differentiation potentials, specifically distinguished by their division rates and expression of markers like Myf5.Good
- Aging and diseases like Duchenne Muscular Dystrophy (DMD) lead to a decrease in satellite cell number and regenerative capacity due to niche changes and continuous demand, necessitating replenishment strategies.Good
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