Research
Hormonal
Aging and diseases like Duchenne Muscular Dystrophy (DMD) lead to a decrease in satellite cell number and regenerative capacity due to niche changes and continuous demand, necessitating replenishment strategies.
As we age or suffer from muscle diseases, our muscle stem cell pool shrinks. This is a key reason why muscle repair becomes harder. Strategies to replenish or protect these cells are critical for maintaining muscle health.
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The number of satellite cells is decreased due to the changing niche during ageing, resulting in attenuation of muscle regeneration capacity. Additionally, in Duchenne muscular dystrophy (DMD) patients, the loss of satellite cell regenerative capacity and decreased satellite cell number due to continuous needs for satellite cells lead to progressive muscle weakness
Why this rating
Review citing clinical observations and mouse models of DMD and aging.
Source
Muscle satellite cell heterogeneity and self-renewal
Norio Motohashi et al. · Frontiers in Cell and Developmental Biology · 2014
DOI 10.3389/fcell.2014.00001
narrative_reviewCited 259×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Muscle satellite cells are a heterogeneous population comprising distinct subpopulations with different self-renewal and differentiation potentials, specifically distinguished by their division rates and expression of markers like Myf5.Good
- Self-renewal of satellite cells is regulated by asymmetric and symmetric division mechanisms, involving specific molecular pathways like p38 MAPK, Notch, and Wnt signaling, which determine whether a cell differentiates or self-renews.Good
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