Research

Micronutrients & recovery

Vitamin D3 supplementation does not significantly improve glucose homeostasis (HOMA-IR, HOMA-B, A1c, fasting glucose) or prevent the progression to type 2 diabetes in adults with normal glucose tolerance, prediabetes, or established type 2 diabetes.

Do not take Vitamin D3 specifically to lower blood sugar or prevent diabetes. While it is important for bone health, this review of over 43,000 patients shows it does not improve glucose control or prevent diabetes progression, regardless of dose or baseline status.

WeakRefutesHIGH confidence
Evidence from available trials shows no effect of vitamin D3 supplementation on glucose homeostasis or diabetes prevention.
Jennifer C Seida et al. · The Journal of Clinical Endocrinology & Metabolism · 2014

Why this rating

High-quality evidence from a systematic review and meta-analysis of 35 RCTs involving 43,407 patients.

Source

Effect of Vitamin D<sub>3</sub>Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis

Jennifer C Seida et al. · The Journal of Clinical Endocrinology & Metabolism · 2014

Meta-analysis · 35 studiesCited 259×
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